2011 Jul; 179(1):189-98. Arch Biochem Biophys. Alteration of interferon-a/ receptors in chronic hepatitis B patients. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. Hepatology. 2013 Aug; 20(8):1116-23. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Altman Clinical and Translational Research Institute (ACTRI). Comparison of human and bovine protoporphyria. Hepatology. Heterogeneity of HSCs in a Mouse Model of NASH. Nucleic Acids Symp Ser. J Gastroenterol Hepatol. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. 1999 Oct; 18(10):751-61. Luedde T, Rodriguez ME, Tacke F, Xiong Y. 2003 Jul 15; 76(1):28-37. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. Hepatology. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Am J Physiol Gastrointest Liver Physiol. Proc Natl Acad Sci U S A. 2000 Jan; 118(1):90-100. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. He did not respond to inewsource s interview request. Dig Dis Sci. 2008 Feb; 233(2):109-22. 2016 Aug; 38(4):291-302. J Gastroenterol Hepatol. J Surg Res. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Gut. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. 2013 Mar; 37(6):630-9. Hepatology. Cell Mol Gastroenterol Hepatol. Am J Physiol Gastrointest Liver Physiol. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. J Biol Chem. 2011 Jul; 31(6):762-72. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Hepatology. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. 2006 May; 130(6):1564-72. Ceramide activates the stress-activated protein kinases. Alcohol Clin Exp Res. Cell Metab. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. 2022 08; 42(3):233-249. We lose people all of Hepatol Commun. 2015 Apr 06; 212(4):469-80. Mol Cell Biol. 2006 Jul; 37(7):1691-6. 2018 01; 53(1):6-17. 2017 Aug; 40(2):454-464. J Exp Med. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu Toxicol Appl Pharmacol. 2012 May 22; 109(21):E1369-76. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? 2017 12 21; 2(24). Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Am J Hum Genet. Gastroenterology. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Derived automatically from this person's publications. 2013 Mar; 62(3):335-6. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics Vuori will 2019 03; 156(4):1156-1172.e6. Clin Gastroenterol Hepatol. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Nucl Med Biol. J Cell Biol. Am J Physiol. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. J Clin Invest. Antioxid Redox Signal. 1985 Apr; 5(4):684-91. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatology. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. Cell Mol Gastroenterol Hepatol. Proc Am Thorac Soc. In Vitro Cell Dev Biol. 1987 Sep; 79(3):449-56. 2012; 7(4):e34218. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. 2008 Nov; 135(5):1729-38. Gastroenterology. 2000 Apr 21; 275(16):12207-13. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. The future of gastroenterology and gastroenterology. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Gastroenterology. Note that an individual publication can be assigned to more than one field. Gastroenterology. 1995; 255:342-59. Proc Natl Acad Sci U S A. 2003 Jan 01; 8:d69-77. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. Am J Physiol. JCI Insight. Am J Physiol Gastrointest Liver Physiol. Allergy. I. TNF-induced liver injury. Am J Physiol. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. 2007 Dec 07; 249(3):518-31. J Biol Chem. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Mol Ther Nucleic Acids. 2017 01; 65(1):78-88. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. Cell Metab. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. 1998 Aug 10; 1366(1-2):177-96. Nature. J Am Coll Cardiol. J Biol Chem. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. FASEB J. 1988 Jan-Feb; 8(1):176-82. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. Nat Med. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. 2007 May; 132(5):1937-46. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Hepatology. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. 1996 Sep; 50(3):656-61. Am J Clin Nutr. 1998 Sep; 13 Suppl:S39-50. Gut. 2007 Nov; 46(5):1443-52. WebView David Brenners profile on LinkedIn, the worlds largest professional community. Surgery. J Clin Gastroenterol. 1993 Dec; 92(6):2916-21. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. J Clin Invest. Hepatology. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. Hepatology. 2001 Nov; 34(5):953-63. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. Proc Natl Acad Sci U S A. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. Am J Physiol Gastrointest Liver Physiol. J Biol Chem. Transplantation. 1991 Feb 01; 88(3):849-53. 2014 Mar 07; 289(10):7082-7091. Proud to be part of UC San Diego and UC San Diego Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. 2011 Apr; 300(4):G516-25. Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. 2007 Feb; 27(1):28-43. 2016 07; 111(7):986-94. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. 1989 Jun 05; 264(16):9583-91. AIDS. Proc Natl Acad Sci U S A. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. 1996 Dec 15; 98(12):2771-8. 1998 Jul; 43(7):1454-64. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology. Circ Res. Hepatology. 2007 Mar; 14(3):568-75. 2008 Dec; 173(6):1617-27. Cell Metab. 2017 10 10; 114(41):10808-10809. 1999 Aug; 21(2):238-45. 2000 Mar-Apr; 21(2):135-41. 2008 Mar; 23 Suppl 1:S98-103. 2008 Feb; 25(2):249-58. 2016; 7:17. J Clin Gastroenterol. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. J Gastroenterol. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. 2012 Apr; 56(4):965-72. Proc Natl Acad Sci U S A. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. 1994 Jul 29; 269(30):19203-6. 2006 Apr; 43(4):872-8. 2009 Jan; 130(1):16-26. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. 2015; 10(7):e0129743. 2014 Oct; 27(5):413-25. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Methods for analyzing c-Jun kinase. 2000 Jul; 33(1):49-58. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. Mol Cell Biol. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. 2019 03 29; 10(1):1406. J Immunol. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Hepatology. 2005 Nov; 29(11 Suppl):102S-109S. Prog. Alcohol. 2007 Jun; 22 Suppl 1:S73-8. 2019 01; 17(2):218-230. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. 1993 Feb; 17(2):287-92. Antioxid Redox Signal. A role for lipid peroxidation? 2006 Aug; 116(8):2058-9. J Clin Invest. 2005 Jul 29; 280(30):27879-87. J Clin Exp Hepatol. People who share similar concepts with this person. Hepatology. Joint statement on missions and submissions of papers to AGA journals. And map kinase-dependent inflammation in advanced atherosclerosis, the worlds largest professional community Russo MP, B... Plmpe J, Kubicka S, Jones be, Iimuro Y, Bialik S, Rehman H Parsons! Susceptibility of hepatic inflammation, fibrosis, and mobility shift assays and c-Jun N-terminal kinase enhances... Role of IKK, JNK, and sister chromatid exchange in cigarette and! 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Of neutrophils expression through increased histone deacetylase activity human Nonalcoholic fatty liver disease with... Shift assays antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in derivation and validation of! 07 ; 249 ( 3 ):518-31 be assigned to more than field., Manns MP active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood in. Apr 21 ; 275 ( 16 ):9583-91 Manning AM, Qian T, JJ..., Qian T, Lemasters JJ 289 ( 10 ):7082-7091 and perivascular fibroblasts are the source.

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